Methotrexate is one of the most commonly used drugs in the rheumatology department and can be used for the treatment of rheumatoid, but has certain toxic side effects. Therefore, before treating rheumatoid, it is necessary to understand the correct use of the drug to avoid adverse reactions and it is recommended to use the drug under the guidance of a doctor. Methotrexate can inhibit cell proliferation, slow down and control the development of rheumatoid disease, and should be done before using blood tests and immune factor tests to determine whether it can work on rheumatoid factor. The specific medication time, frequency and dosage should be strictly enforced according to your own medical advice. 2. When methotrexate is effective and no other adverse reactions occur, it can be used for a long time. However, if the transaminase level rises to more than three times the normal level during the medication period, it is necessary to stop the medication immediately and wait until the transaminase level gradually returns to the normal level before adjusting the medication; 3. . Second, methotrexate precautions 1, methotrexate adverse reactions occur mainly in normal or rapidly proliferating tissues, initially manifested as oral ulcers, with the continuous action of the drug, there will also be a decrease in white blood cells, decreased resistance, nausea, vomiting, etc.; 2, in the dose of methotrexate with the increase in the course of treatment, may cause harm to liver and kidney function, so it is recommended that about a month after the use of the drug liver and kidney For patients who need to use methotrexate for rheumatoid treatment, it is recommended that blood and urine tests and liver and kidney function tests should be performed once every two weeks for the first three months of use, and then once every 1-3 months. Methotrexate alone is not enough for the treatment of rheumatoid arthritis. If necessary, comprehensive treatment with general therapy, surgery or plasma exchange and immunosorbent is needed.