Eating watermelon will not cause kidney failure, but patients with kidney failure should control the amount of watermelon. Renal failure is the end stage of various chronic kidney diseases, such as chronic glomerulonephritis, hypertensive nephropathy, diabetic nephropathy, etc. At this time, the kidney’s drainage and endocrine dysfunction, which can lead to the body to appear in the water, electrolyte and acid-base balance disorders as well as a group of systemic symptoms of the disease. Kidney failure patients due to drainage disorders, and most of the components of watermelon are water, if the intake of too much and can not be discharged in a timely manner, may appear edema, heart failure and other symptoms, so need to control the intake of watermelon. Patients with renal failure are advised to go to regular hospitals in time and standardize the treatment under the guidance of doctors.