If the postoperative pathological examination result shows that the excised melanoma is benign tumor, generally there will be no proliferation and the prognosis is better. If the postoperative pathological examination results show that the excised melanoma is a malignant tumor, there may be microscopic lesions not found in other parts of the body, which have a higher chance of metastasis and a faster metastasis rate, so there is a possibility of spread. In contrast, the chance of malignant melanoma spreading depends on the stage of the tumor, which is related to the extent of tumor confinement, lymph node metastasis and distant metastasis. The earlier the staging, the less lymph node and distant metastasis, the less possibility of spread; the later the staging, the more lymph node and distant metastasis, the more possibility of spread. Therefore, local enlargement resection should be performed surgically, and lymph node dissection can be performed about one month after surgery to remove the metastatic tumor from other parts to prevent recurrence. In addition, postoperative adjuvant therapy also plays a certain role in tumor spread. Therefore, patients should pay attention to regular review after surgery, observe the recovery of the surgical site, and follow medical prescriptions for anti-infection and other treatments. At the same time, patients should pay attention to control their own diet. After surgery, they can eat semi-liquid food with high vitamin, high protein, high fiber and rich nutrition to supplement body nutrition, and promote gastrointestinal peristalsis to prevent constipation. After wound recovery, avoid strenuous exercise, avoid sun exposure, maintain adequate sleep, pay attention to proper exercise to enhance the body’s immunity, and maintain a good state of mind.