In almost every one of us, there are some “black moles” in one way or another. Most of them are like a dead volcano that will gently accompany us for the rest of our lives. However, there are some “black moles” that are a volcano that can erupt at any time and endanger our lives once they “erupt”. Such erupting “moles” are “malignant melanoma”. ”Malignant melanoma is a tumor with a very high degree of malignancy. It mainly occurs on the soles of the feet and palms of the hands. It appears as a black lump on the surface of the skin, sometimes in the shape of a cauliflower, and grows rapidly, and the wound does not heal for a long time after ulceration. Malignant melanoma on the body surface mainly grows in the plantar area, and a few can be in the palm of the hand, chest and abdomen. In the early stage, it is a black mole, but due to long time walking and friction, it leads to malignant transformation. However, some patients are stimulated by “pedicure” and “laser beauty treatment”, which lead to malignant tumor. Therefore, it is recommended that patients with moles on the soles of the feet and palms of the hands should go to the hospital for examination in a timely manner, and should not go to pedicure stores or beauty salons for treatment on their own initiative. Due to the high malignancy of the disease, various treatment measures currently cannot achieve the purpose of eradication. Once metastasis occurs, it can be life-threatening. Research has confirmed that the most effective treatment for the disease is surgical removal, and the earlier the treatment, the better the results.