Cuticle hardening on the edge of the nail needs to be treated according to the cause, general treatment or medication, common causes include local skin friction, onychomycosis and so on. 1. local skin friction: local skin friction caused by keratosis pilaris, need to pay attention to reduce friction, moisturizing care, can be applied through the hand cream, vitamin E cream, and local use of exfoliating ointment, such as salicylic acid ointment, urea ointment and so on. 2. Onychomycosis: Onychomycosis caused by keratosis hardening on the edge of the nails, can be applied locally 5% amorphophallus application, can also be taken orally antifungal drugs, such as terbinafine, itraconazole, etc., pay attention to keep the foot hygiene and dryness. The above medications should be used under the guidance of a doctor. There may be other causes of keratosis hardening on the side of the nails, it is recommended to go to the hospital in time to improve the examination, to clarify the cause of the disease and then give targeted treatment.