Ezetimibe is a cholesterol-lowering drug that can cause side effects such as gastrointestinal discomfort and fatigue. Ezetimibe is an oral lipid-lowering drug that reduces blood cholesterol levels by inhibiting the absorption of cholesterol in the small intestine. It can be used alone or in combination with statins, and its use may cause a variety of side effects that are related to individual responsiveness. Common side effects include abdominal pain, diarrhea, weakness, fatigue, elevated transaminases, and muscle pain. Ezetimibe is used with caution in pregnant and lactating women, and is contraindicated in people who are allergic to any of the ingredients, active liver disease, and unexplained persistent elevation of liver enzymes. People with hypercholesterolemia need to be treated under the supervision of a physician, and if there is any discomfort after using the drug, it is necessary to stop the drug and consult a doctor.