Knee posterior hamstring pain according to the specific cause, give general treatment, physical therapy, physiotherapy, drug therapy and other measures, pain does not relieve, surgery is recommended. 1. Osteoarthritis: knee osteoarthritis caused by wear and tear of articular cartilage, avoid going up and down the stairs or mountaineering activities, strengthen the quadriceps muscle exercise, walking on crutches or walkers to reduce the load, the application of pain medication (diclofenac sodium tablets, flurbiprofen ester cream) and nutritive cartilage medication (aminoglycans, chondroitin sulfate), the joint cavity injection of sodium vitrate. If the pain is not relieved, joint replacement surgery should be performed. 2. For pain caused by knee meniscus injury, local braking, immobilization with support, application of pain relieving drugs (diclofenac sodium tablets, flurbiprofen ester cream) and anti-swelling drugs (diosmet tablets) are recommended. If the pain is not relieved, meniscal suture or meniscectomy is feasible. 3. Pain caused by cyst in popliteal fossa, if the cyst is small and has no pressure on the surrounding tissues, massage and physiotherapy (infrared ray) can be given. If the cyst increases in size and has pressure symptoms on tendons, ligaments and surrounding blood vessels and nerves, surgery is recommended to remove the cyst. Standing up after squatting knee hamstring pain in the posterior fossa is recommended to actively seek medical attention, physician guidance under the diagnosis and treatment.