High creatine kinase isoenzyme can be seen in a variety of disease states. For elevated creatine kinase isoenzyme, it is often necessary to combine creatine kinase levels, electrocardiogram, and the patient’s symptoms and signs to make a comprehensive judgment: 1. muscle injury: simultaneous elevation of creatine kinase and creatine kinase isoenzyme suggests muscle injury. 2. myocardial infarction: normal creatine kinase and elevated creatine kinase isoenzyme often suggest coronary artery disease and myocardial infarction. 3. 3. shock: shock can also cause high creatine kinase isoenzyme. 4. endocrine diseases: hypothyroidism, for example, can cause an increase in the corresponding enzyme. 5. other diseases: respiratory diseases, cerebrovascular diseases and skeletal muscle injury can also cause high creatine kinase isoenzyme, which needs to be combined with the patient’s symptoms, signs, electrocardiogram, cardiac ultrasound and other tests to make a comprehensive judgment. It needs to be combined with the patient’s symptoms, signs, ECG, cardiac ultrasound and other tests to make a comprehensive judgment.