Vomiting after craniotomy is often caused by painful stimulation or intracranial hypertension, or in some special cases by recurrent cerebral hemorrhage, so symptomatic treatment and causative therapy must be combined. The first step is to apply metoclopramide for intramuscular injection, which can effectively improve the vomiting situation. If it is not effective, intravenous granisetron can be applied for treatment. If there is still no effect, it is important to review the head CT to observe the specific intracranial changes. If the cranial brain shows a diffuse swelling process, it is necessary to apply mannitol for dehydration and cranial pressure lowering treatment. A rapid drip of 250 ml of mannitol within 10-20 minutes can effectively reduce intracranial hypertension. Secondly, if the vomiting is caused by recurrent cerebral hemorrhage, then another surgical treatment is needed to save the patient’s life.