Shiitake mushroom poisoning is a type of poisonous mushroom poisoning, and its clinical symptoms include: mild poisoning may have clinical symptoms such as nausea, vomiting, abdominal pain, peribulbar colic, accompanied by mucus-purulent stools or even bloody stools. Symptoms of moderate mushroom poisoning may include clinical signs such as tachycardia, arrhythmia, chest tightness and shortness of breath, and discomfort in the precordial area. In severe cases, there may be coma, accompanied by clinical symptoms of transient loss of consciousness and shock, as well as symptoms of cyanosis of the face and lips. Gastric lavage can be performed with warm water until the gastric juice is clear and colorless. Second, after gastric lavage can be treated with enema, the method of diarrhea is an important part of the rescue, can apply magnesium sulfate or mannitol to perform high enema. Special antidotes can be applied, such as mushroom poisoning can be selected from the dithiobutyric acid disodium group of special antidotes. Four, in the hospital with conditions can apply blood purification treatment.