Collagenase chemolysis: It is also called “chemical nucleolysis”. Under the guidance of C-arm X-ray machine or CT, collagenase is accurately injected into and around the herniated disc to dissolve and absorb the herniated disc and release its compression on the nerve root, with an excellent rate of over 90%. Since this treatment method is less invasive, has fewer complications, and has reliable efficacy, it has become one of the most effective minimally invasive interventional treatment methods for cervical spondylosis and lumbar disc herniation caused by disc herniation, in addition to surgical methods. Indications Clearly diagnosed cervical spondylosis or lumbar disc herniation with one of the following conditions can be considered for collagenase lysis: 1. unilateral lumbar and leg pain with obvious nerve root compression symptoms; 2. eligible for surgical resection; 3. ineffective after 1 to 3 months of regular conservative treatment Contraindications The following patients should be treated with caution: 1. disc herniation with bony spinal stenosis; 2. all or most of the herniated material Calcification; 3, ossification of the ligamentum flavum and the posterior longitudinal ligament; 4, discitis or intervertebral infection; 5, free protrusion; 6, cauda equina syndrome. Advantages 1, can achieve the purpose of radical treatment of the disease caused by herniated disc, collagenase has specific solubility, can dissolve the herniated disc tissue, release its compression of nerve roots and spinal cord. After the operation, pay attention to rest and rehabilitation exercises, generally not easy to recur. 2.High safety, accurate access to the injection site under CT guidance, no damage to nerves, blood vessels and other important structures. 3.Little trauma, little pain. No damage to bone and ligaments, and the integrity of the spine is maintained. No pain during operation. 4.Low cost and short hospitalization time. Generally, 5 to 9 days can be discharged from the hospital, which reduces the economic burden of patients. Methods Intradiscal injection Extradiscal injection Epidural interspace placement injection of intervertebral foramen Anterior interspace method of sacral fissure Post-treatment treatment Position Prone position or affected side position for 8 hours after treatment, followed by transfer to supine position. Absolute bed rest for 24 hours, followed by flat rest for 7 days. Abstain from seafood for 1 week. Anti-inflammatory, anti-swelling, analgesic and nerve-nourishing treatment is given according to the severity of pain. Side effects and complications The following complications can be completely avoided as long as the operation is standardized. 1. Postoperative pain rarely increases. 2. Rarely urinary retention and intestinal paralysis. 3. Minor pain in the puncture wound after the operation. 4.Infection of the intervertebral space. 5.Nerve injury.