The causes of cold hands and feet in girls include yang deficiency, insufficient qi and blood, and wind-cold sensation, etc. Yang tonic, qi and blood tonic, as well as pungent and warming antidepressant medicines can be used to regulate them respectively. 1. Yang tonic drugs: commonly used drugs include Jin Gui Ren Qi Pills and Yu Gui Pills, which have the effect of warming and tonifying yang qi, and are used to treat cold hands and feet due to yang deficiency, as well as symptoms such as fear of coldness, frequent urination, and nocturnal polyuria. The adverse effects of Jin Gui Ren Qi Pill are not clear. Pregnant women should not take it, and people with Yin deficiency and internal heat should take it with caution. 2. Qi and blood tonic drugs: Oral Liquid of Ten Complete Mending and Oral Liquid of Benefiting Qi and Nourishing Blood (replenishing the body’s qi and blood) are commonly used to tonify qi and blood, and are used to treat cold hands and feet due to qi and blood deficiency (deficiency of both qi and blood), as well as to treat shortness of breath and a white, lackluster complexion, and fatigue (mental fatigue and physical weakness). 3. Pungent and warming medicines to relieve the epidermis: Epiglottis Cold Granules and Wind-Cold Cold Granules are commonly used for cold hands and feet due to wind-cold and can treat symptoms such as fear of coldness and runny nose, as well as stiffness and pain in the head and neck. Girls with cold hands and feet may also be other causes, please consult the hospital in time, the specific treatment plan, need to be identified by the doctor for better treatment of the disease. The above medications should be used under the guidance of a doctor.