Some friends were diagnosed with dry syndrome in hospital and at the same time were diagnosed with primary biliary cirrhosis (PBC). In fact, it is not very likely that these two diseases exist at the same time, and most cases are secondary to cholestasis in dry syndrome. In general, the treatment effect and prognosis of cholestasis secondary to dry syndrome is much better than that of primary biliary cirrhosis (PBC) combined with dry syndrome. The details of how to identify it will not be detailed here. Cholestasis secondary to dry syndrome has the manifestations of dry syndrome and also positive anti-mitochondrial antibody (AMA), elevated immunoglobulin IgM, elevated serum alkaline phosphatase (ALP), and glutamyl transaminase disproportionately elevated with serum bilirubin and transaminase. The treatment of cholestasis secondary to dry syndrome is better with the combination of Chinese and Western medicine, and there are various specific treatment methods, taking Chinese medicine should be individualized, and western medicine is mainly ursodeoxycholic acid (Ursodeoxycholic acid, UDCA) and motilmic acid (primaquine). Chinese medicine to a certain stage, such as glutamyl transaminase, bilirubin, transaminase has been normal, can be changed to two days once a dose, gradually changed to 3 days once, do not stop taking Chinese medicine. Usfer should also be taken for a long time, and as for primaquine, it is decided whether to take it for a long time according to individual situation. In conclusion, the treatment of cholestasis secondary to dry syndrome is a long-term process, which can be relieved for a long time if controlled properly.