5 clinical symptoms that should not be ignored: 1, chest pain Chest pain or pressure tightness is a common manifestation of coronary heart disease attacks. If it persists without relief, it is best to seek immediate medical attention. 2, lower extremity pain The pain or weakness of the lower extremities accompanied by walking may be a manifestation of peripheral artery disease, and is often associated with coronary artery disease. 3, shortness of breath The sudden appearance of shortness of breath and wheezing during daily activities may indicate cardiac insufficiency, coronary heart disease or heart valve disease. 4, syncope Syncope may be a sign of arrhythmia, hypotension, aortic stenosis, or other cardiovascular disease. 5, palpitations without a cause to feel obvious panic discomfort, this may be a manifestation of arrhythmia. The arrhythmia is often a symptom of heart disease.