The common causes of itchy and painful blisters on the soles of the feet include tinea pedis, psoriasis, and palmoplantar pustulosis. 1. herpes pemphigoid: this disease is also known as tinea pedis, mainly caused by fungal infections, common causative organisms, including Trichophyton rubrum, Trichophyton mustelii, gypsum-like microsporidiomycetes, flocculent epidermid fungi, etc., occurring between the toes of the foot, soles of the foot, foot lateral margins, etc., manifested as a blister of clear blisters, thick and shiny wall, not easy to break, can be fused into a large blisters, itching, pain, and other symptoms. 2. Sweat herpes: the etiology and pathogenesis of this disease is unknown, may be associated with mental tension, excessive pressure, sweaty hands and feet, fungal infections, etc., occurring on the palm surface and soles of the feet, lesions are manifested as small blisters deep in the epidermis, the size of a needle tip to a grain of rice, the blisters contain clear liquid, itching, burning sensation, pain and other symptoms. 3. Palmoplantar pustulosis: the etiology is unknown, may be related to smoking, stress, drugs and so on. Clinically, it is mainly manifested as aseptic pustules on the palms of the hands and soles of the feet, which may be accompanied by itching and stinging sensation. It is recommended that patients go to the regular hospital dermatology department, after diagnosis, timely treatment in accordance with the doctor’s instructions, to avoid delaying the condition, usually pay attention to the cleanliness and hygiene of the skin.