The appearance of blisters on the hands is mainly due to the separation of the epidermis and subcutaneous tissue produced by sports friction to form a gap, the gap is filled with tissue fluid, thus forming blisters. If the blister skin is still intact, it should be retained, only need to draw out the liquid inside the blister, and then sterilize the bandage, the blister skin can protect the wound, which is conducive to wound healing. If the blister skin has been torn off, it can be wrapped with a sterile oily dressing (e.g., petroleum jelly gauze). The dressing does not need to be changed frequently to avoid damage to the neoplastic epithelium, but it should be changed diligently when there is wetting of the dressing, odor or other signs of infection, and purulent secretions from the wound should be removed. Keeping the wound clean is conducive to healing. It should be noted that when handling the blisters by oneself, care should be taken to sterilize the instruments to avoid infection. If the blister is large, the risk of infection is higher due to the lack of asepsis awareness, and medical attention should be sought promptly. Hand work blisters recommended timely medical treatment, under the guidance of a professional doctor standardized treatment, in order to avoid delays in the condition.