Human blood pressure is affected by many factors, including the seasons and climate. The change of seasons affects not only resting blood pressure, but also exercise blood pressure. The blood pressure of people with hypertension also varies seasonally, and the variation is greater than that of normal people. Excluding the interference of special factors, in the natural state, the blood pressure of patients with hypertension is higher in the fall and winter and lower in the spring and summer. Some patients may also experience fluctuations in blood pressure during the seasonal changes in March and April and October each year. The reasons for seasonal changes in blood pressure are related to temperature, neuroendocrine activation, and increased sodium excretion load of the kidneys. In autumn and winter, as the body cools, blood pressure increases due to vasoconstriction in order to reduce heat dissipation, and more patients visit the clinic for hypertension and its complications during this season. Therefore, we should measure blood pressure diligently during seasonal changes and adjust the type and dose of blood pressure-lowering drugs in a timely manner. In winter, if the blood rises, the medication should be increased appropriately to prevent a sudden rise in blood pressure and the resulting cardiovascular and cerebrovascular events. In summer, according to the lowering of blood pressure, the antihypertensive medication should be reduced at the right time to prevent low blood pressure and the resultant insufficient blood supply to the brain, heart and other vital organs.