Numbness in both legs is usually treated with anti-inflammatory and analgesic drugs and nutritive nerve drugs; it is commonly caused by improper posture or exercise, herniated lumbar discs, diabetic peripheral neuropathy, sciatica, and so on. 1. Improper posture or exercise: change bad habits and make basic preparations before exercise. 2. Herniated lumbar intervertebral disc and sciatica: anti-inflammatory and analgesic drugs such as ibuprofen, diclofenac sodium and celecoxib can be used to relieve pain; nutritive nerve drugs such as methylcobalamin and vitamin B1 can be used to repair the damaged nerves and reduce the local symptoms. 3. Diabetic peripheral neuropathy: applying hypoglycemic drugs such as metformin under the guidance of physicians to effectively lower sugar, and nutritive nerve drugs such as methylcobalamin to improve nerve symptoms. In addition, intracranial diseases and spinal cord lesions can also cause numbness of legs, generally according to the cause of the treatment, such as the use of mannitol to lower the cranial pressure, aspirin antiplatelet aggregation, alteplase intravenous thrombolysis, atorvastatin to lower the blood lipids, enalapril to lower blood pressure and so on. Surgery is feasible when necessary. The causes of numbness in the legs are more, it is recommended that patients seek medical attention in a timely manner, under the guidance of the physician to strictly comply with the doctor’s instructions, not blindly self-medication, so as not to cause adverse consequences.