If bleeding hemorrhoids occur while taking warfarin, medication adjustments may be necessary. Warfarin is the most commonly used vitamin K antagonist, affecting the coagulation process by preventing the conversion and utilization of vitamin K in the body, thus acting as an anticoagulant. It is routinely used in the clinic to combat thromboembolic disorders caused by atrial fibrillation and heart valve disease; adverse effects are mainly spontaneous bleeding caused by overdose, so the use of the drug requires the measurement of prothrombinogen. If hemorrhoidal bleeding occurs while taking warfarin, drug dose adjustment may be necessary. Otherwise, hemorrhoidal hemorrhage may occur due to the anticoagulant effect of warfarin, which may cause, for example, a decrease in blood pressure or even shock. Adjustment of drug dosage or even type needs to be done under the supervision of a physician.