If tumor fever causes fever in cholangiocarcinoma patients, it is generally difficult to reduce fever. If the fever is caused by infection in cancer patients, it is mostly possible to reduce fever. 1. Fever may be caused by rapid growth of malignant tumor, which causes tissue ischemia and hypoxia necrosis or release of tumor necrosis factor, or endogenous pyrogen produced by malignant tumor, and fever occurs, and it is difficult to reduce the fever in this case as the cancer cannot be cured. 2. It is also possible that the patient’s physical quality is poor, and the patient has bacterial or viral infections that cause fever. In this case, after active anti-infection and other treatments, the fever can usually be reduced.