CA125 (glycan antigen 125) 970,000 U/L is elevated significantly, suggesting a higher likelihood of malignancy or the possibility of tumor progression. CA125 is an important tumor marker with normal value of 0-3.5 million U/L. 1. Ovarian cancer: CA125 is present in ovarian cancer tissue cells and plasma adenocarcinoma tissue, but not in mucinous ovarian cancer. The level of CA125 in patients with ovarian epithelial cancer can be significantly elevated, and the sensitivity of early diagnosis and recurrence diagnosis can reach 50%-90%; 2. It can be used to identify ovarian masses, especially for postmenopausal women; 3. cervical cancer, breast cancer, pancreatic cancer, biliary tract cancer, liver cancer, gastric cancer, colon cancer, lung cancer, etc. will also be elevated; 4. serum CA125 is also significantly elevated in a small number of patients with benign ovarian tumors and uterine fibroids, but usually not more than 100,000 U/L; 5. Serum CA25 can also be elevated in patients with decompensated cirrhosis, chronic hepatitis, and endometriosis, but the magnitude of elevation is usually low; In conclusion, abnormal elevation of CA125 needs to exclude the possibility of tumor or progression after treatment, especially in patients with significant elevation. It is recommended to go to a regular hospital for a comprehensive assessment of the condition. It is necessary to choose the department of initial diagnosis based on one’s symptoms, past medical history or family history, etc., improve other blood tests, ultrasound, CT and other imaging tests, and choose pathological tests to confirm the type of pathology according to the situation.