Lymphatic reflux obstruction usually leads to localized swelling due to lymphatic reflux obstruction. For example, if it occurs in the legs, rubbery legs may appear. Some patients may develop infection after swelling, which may manifest as vesicles, pus, fever, etc. Once this happens, first of all, active symptomatic treatment is needed, choosing sensitive antibiotics such as penicillin to fight the infection, as well as an examination to clarify the cause of the lymphatic reflux obstruction, and then treating the cause. For example, lymphatic reflux obstruction caused by trematodes can be treated with praziquantel or albendazole, and attention should be paid to elevating the affected limb and strengthening nutritional support to protect the function of the organs.