High gamma-glutamyltransferase suggests a visit to hepatology and general surgery. High gamma-glutamyltransferase is generally indicative of abnormal liver function and is commonly associated with liver or biliary tract disease. The most common causes are viral hepatitis, alcoholic liver disease, fatty liver, excessive alcohol consumption, and gallbladder obstruction. 1. Viral hepatitis needs to take antiviral drugs in time, need to go to the hospital in time, clear diagnosis, after antiviral treatment liver function will improve, γ-glutamyl transferase will fall. 2. Excessive alcohol consumption, alcoholic liver disease or fatty liver may lead to liver function abnormalities, it is recommended to quit drinking, pay attention to rest, regular review. 3. Gallbladder obstruction is usually caused by gallbladder stones, if the stones are not big, you can take oral medication to dissolve the stones, if the stones are big, it is recommended to go to the general surgery department to determine whether surgery is needed. If the long-term γ-glutamyl transferase is high for a long time, it is recommended to go to the hospital to consult the Department of Hepatology or General Surgery, to clarify the cause of the disease, targeted treatment.