Stones may grow in women or in men, and there is no absolute correlation between the clinical symptoms and gender. Once a stone becomes symptomatic, it usually causes pain. An embedded stone in the ureter can cause severe pain in the right or left side of the abdomen or in the posterior lumbar region, and because of the embedded stone and obstruction, it can cause poor drainage of the kidney, which can lead to severe perinephric fluid accumulation. In addition, stones in the biliary system are rarely detected if they are asymptomatic, such as those within 3 mm in diameter. If the stones are large, they may cause abnormalities in the diet, such as pain after eating greasy food, pain in the upper abdomen or pain and nausea after heavy drinking or overeating, and in severe cases of obstruction or infection in the biliary system, the pain may radiate locally in the form of colic, and also cause The pain can also cause pain in the shoulder and back.