Mononitrate should refer to isosorbide mononitrate, there is no exact stopping time, there are individual differences, usually need to take long-term drug treatment. Isosorbide mononitrate oral drug is mainly used for long-term treatment of coronary heart disease and chronic heart failure, prevention of angina pectoris, treatment of persistent angina pectoris after myocardial infarction, combined with digitalis or diuretics for the treatment of chronic congestive heart failure, the treatment of pulmonary hypertension and so on. Patients use isosorbide mononitrate treatment time varies from person to person, there is no specific stopping time, some patients can stop using two or three months, some patients need to use long-term medication, it is recommended that patients follow the doctor’s instructions to use and stop using the drug. Patients may experience dry mouth, weakness, chest pain, back pain, flu-like symptoms, rigors, hypertension, heart failure, flushing, vertigo, ptosis, migraine, abdominal pain, diarrhea, tongue inflammation, hemorrhoids, tympanic membrane perforation, tinnitus, purpura, insomnia, coughing, renal stones and other adverse reactions after taking the drug, and in severe cases, myocardial infarction, arrhythmia, dyspnea, and so on. This product is prohibited for patients who are allergic to nitrite or other nitrates or have special reactions. It is recommended that patients who feel unwell go to regular hospitals for timely consultation and follow the doctor’s instructions for symptomatic treatment.