Patients with vague pain under the right rib margin are associated with more diseases, such as liver function impairment, lung infection, pleurisy, gastroduodenal ulcer, etc., which can lead to vague pain sensation under the right rib cage. The symptoms and the patient’s subjective feelings can be used clinically to find the cause, clarify the diagnosis, and provide treatment so that the patient’s symptoms can be reduced. In case of viral hepatitis, alcoholic liver damage, gallstone disease, etc., treatment can be provided to address the cause, such as anti-hepatitis virus, surgical removal of stones, and alcohol cessation. If a gastroduodenal ulcer or even H. pylori infection is found under gastroscopy, anti-H. pylori treatment is required, usually requiring a quadruple dose of drugs such as loxacillin and amoxicillin to correct it, as well as the application of drugs to protect the gastric mucosa. In case of lung infection or pleurisy, pulmonary nebulization therapy or even puncture and release of pleural fluid is required if necessary, which can effectively improve the patient’s symptoms.