Newborns spitting up sleepiness and lack of spirit, may be related to gastroesophageal reflux, may also be due to milk protein allergy, gastroenteritis and other reasons. 1. Gastroesophageal reflux: Because the gastrointestinal tract of newborns is still immature, the stomach is mainly horizontal, and the lower esophageal sphincter is flaccid, which can easily cause gastroesophageal reflux, resulting in reflux of gastric contents, which can lead to spitting up, lethargy, and dysphoria. 2. Milk protein allergy: especially some of the newborns who are allergic to milk protein are likely to be allergic to milk protein, which may show spitting up, drowsiness, mental instability, and may be accompanied by abdominal distension, diarrhea and other manifestations. 3. gastroenteritis: due to the newborn’s own immunity and resistance is poor, if not fed properly, it is likely to induce gastroenteritis, in the inflammation of the stimulus, may cause spitting up, lethargy, lack of spirit, may also be accompanied by abdominal pain, diarrhea and other symptoms. Newborns spitting up sleepiness and lack of spirit, may also be related to other factors, it is recommended to seek medical attention as soon as possible, through the perfect relevant examination, diagnosis of the cause, give targeted treatment.