High transaminase during pregnancy is not recommended to take liver-protecting drugs directly, physiological factors do not need to take liver-protecting drugs. Pathological factors need to be under the guidance of the doctor to choose compound glycyrrhizin, ursodeoxycholic acid and other liver-protecting and enzyme-lowering drugs. During pregnancy, because of high hormone levels or intake of high-fat food, there may be a rise in aminotransferases and other phenomena, at this time do not need to take hepatoprotective drugs. Adjust the diet structure, after delivery will naturally recover. Pathological factors include acute fatty liver in pregnancy and intrahepatic cholestasis in pregnancy, which require careful selection of liver-protecting and enzyme-lowering drugs under the guidance of a doctor, such as compound glycyrrhizin, ursodeoxycholic acid, etc., and termination of pregnancy may be required if necessary. The treatment of high aminotransferase in pregnant women needs to be combined with the treatment of the individual’s situation, should be under the guidance of a doctor, and is not recommended to treat blindly.