Duodenum descending submucosal elevation 1cm consider occupying lesion, may be benign tumor or malignant tumor, need to improve the ultrasound endoscopy under the guidance of the doctor, etc., for treatment. The presence of 1cm of submucosal elevation in the descending part of the duodenum is considered to be a submucosal tumor, and it is recommended to improve other examinations, such as ultrasonic endoscopy, abdominal CT and other examinations to clarify the nature of the lesion. If it is a benign tumor, endoscopic resection or partial duodenal resection can be performed; if it is a malignant tumor, surgical resection is recommended, and if necessary, combined with radiotherapy or chemotherapy, or preoperative neoadjuvant chemotherapy to reduce the stage of the tumor, which will improve the probability of success of surgical treatment. In case of 1cm elevation of submucosa in the descending part of duodenum, it is recommended to go to the hospital and ask the doctor to make a judgment and clarify the cause of the disease.