Urine protein three plus sign is how, in this case it is recommended that the patient re-test to see whether the urine protein is normal, still have three plus sign or more plus sign, according to the patient’s clinical manifestations of the diagnosis of the disease, for example, some patients have eyelid or lower limb swelling, plus proteinuria three plus sign may be proteinuria. It may be a renal disease such as glomerulonephritis, nephrotic syndrome, or some patients have diabetes, hypertension, it may be due to diabetes and hypertension caused by renal impairment and proteinuria, need to further do 24-hour urine protein quantification to determine whether it is proteinuria or not.