Lung adenocarcinoma compressing nerves will cause pain and abnormality of corresponding innervated area, and the treatment includes medication, surgery, radiotherapy and so on, and the medication should follow the doctor’s instruction. 1. Pain: non-steroidal anti-inflammatory drugs such as diclofenac sodium can be used. 2. Treatment for the cause: lung adenocarcinoma causes nerve compression, mainly for tumor treatment, such as surgical resection, chemotherapy, radiotherapy and so on, chemotherapy drugs such as cisplatin and so on. Tumor compression of sympathetic nerve can cause pupil shrinkage, drooping eyelid, sunken eyes and other symptoms, and the treatment is mainly directed to the cause of the disease, such as surgical resection of the tumor. Tumor occurring in the apical part of the lung is easy to compress brachial plexus nerve, which in turn causes severe pain and sensory abnormality in the shoulder joint and inner side of the upper limb on the same side, presenting radiating pain, and the treatment can be chosen as surgical resection of the tumor. Lung adenocarcinoma compresses nerves, it is suggested that patients should seek medical treatment in time and cooperate with doctors to receive regular treatment.