Cough with thick sputum may be caused by cold, pneumonia or bronchitis, etc. Depending on the condition, you can choose medication as well as general treatment. 1. Cold: If it is caused by cold, during the treatment, you should pay attention to adjust the diet, eat some light and nutritious food, appropriate outdoor exercise and fresh air. If necessary, the patient can also take drugs such as external wind-cold granules and Jingbao granules under the guidance of the doctor. 2. Pneumonia: according to the different pathogens to choose the appropriate antibiotics, such as pneumococcus caused by pneumonia, can choose penicillin, cefotaxime, ciprofloxacin, etc.; Mycoplasma pneumonia caused by pneumonia is generally preferred to macrolide antibiotics, such as azithromycin and so on. 3. Bronchitis: bronchitis patients cough with thick phlegm symptoms are obvious, can be used to relieve cough phlegm drugs, such as brown composite, and aminoglutethimide hydrochloride, etc., there is evidence of bacterial infection can also be taken amoxicillin, cephradine and other drugs. Cough with thick phlegm patients should go to the hospital in time for examination, according to the specific causes, under the guidance of the doctor to use medication to prevent the condition from worsening.