Swelling of the hand after being stuck by durian is usually considered to be caused by secondary infection. Hand by durian, resulting in damage to the integrity of the skin, if not timely treatment or frequent exposure to water, the microbes are likely to infect the wound, the wound will appear red, swollen, hot, painful. Patients should keep the wound clean and dry, avoiding water, local application of iodophor, alcohol disinfection treatment, and then use sterile gauze bandage, regular medication. Small wounds usually heal in 2-4 days and usually do not cause serious complications. If the wound is larger or the infection is more serious, it can be treated with some antibiotic drugs such as cefaclor and amoxicillin under doctor’s supervision. During the treatment period, we should pay attention to a light diet, avoid spicy and stimulating foods, and eat more foods rich in vitamins. If the infection is more serious, the patient should go to the hospital in time and be treated under the doctor’s guidance.