Hypertension and enlarged prostate are not contraindications to the use of tadalafil, impotence patients with these diseases can take it after excluding other contraindications to the use of the drug, the specific use of the drug must follow the doctor’s instructions. Impotence is known as erectile dysfunction, and tadalafil is one of the most commonly used medications for the treatment of this disease. Hypertension and prostate enlargement are not listed as absolute contraindications to tadalafil, so patients with erectile dysfunction who have a combination of these two diseases can take the drug normally after excluding contraindications such as allergy to tadalafil and taking nitrate drugs (e.g. isosorbide mononitrate, nitroglycerin, etc.). However, it should be noted that patients with hypertension may have uncontrolled blood pressure, tadalafil should be used with caution; in addition, tadalafil may also enhance the antihypertensive effect of antihypertensive drugs, if the combination of the need to pay attention to observe the reaction after the use of the drug. It should also be noted that the use of tadalafil process may occur headache, nausea and other adverse reactions. In summary, if the combination of hypertension and prostate enlargement of erectile dysfunction patients do have the need to use tadalafil, it is necessary to use the drug under the guidance of a doctor, and closely observe the efficacy of the drug and the reaction, once there is maladaptation promptly seek medical treatment. Do not blindly use the drug or increase or decrease the dosage on your own to avoid adverse consequences.