The fastest way to stop the pain of hot peppers on hot hands includes using vinegar to neutralize the capsaicinoids after rinsing with plenty of water, as well as applying an ice cube externally to stop the pain. The main reason chili peppers cause hand pain is because they contain capsaicin. Capsaicin causes burning, pain, and redness in the epidermis of the body after it comes into contact with the epidermis. Capsaicin is an alkaline substance, once stuck on the hands, you can first use a lot of water to rinse, or use soap and water, hand sanitizer to wash the capsaicin as clean as possible, and then use vinegar to neutralize capsaicin. If you still feel pain, you can use cold ice to help analgesia, redness and swelling can be convergence with glycerite. You can wear gloves when cutting peppers to prevent similar symptoms. If the discomfort is unusually pronounced, it is recommended to seek medical attention.