High ApoA can be seen in physiological phenomena, as well as drug use, alcohol consumption, special physiological periods, and chronic active liver disease; low ApoB is mainly seen in liver disease and myocardial ischemia. Both ApoA and ApoB are protein components of plasma lipids that bind and transport blood lipids to various tissues of the body to participate in metabolism. Through their functioning, they can influence the level of cholesterol and lipids in the blood, thus affecting the process of atherosclerosis, cardiovascular and cerebrovascular diseases. If ApoA is slightly elevated, a transient elevation due to physiologic factors cannot be ruled out and can be reviewed. Elevated ApoA is commonly seen after certain medications, such as antiepileptic drugs, which can be elevated after treatment and improve when the drug is discontinued. ApoA can also be elevated when measured immediately after heavy alcohol consumption. ApoA is elevated in pregnant women due to their specific physiology. Also, patients with chronic hepatitis and cirrhosis may have high ApoA. Low calprotectin B, if not obvious, can be seen in physiological factors, usually transient, and can be rechecked. Pathologic factors are mainly seen in some liver diseases, such as hepatitis, cirrhosis, and hepatocellular carcinoma. At the same time, myocardial ischemia and coronary heart disease can also be found in low ApoB. It is recommended to consult the doctor as soon as possible, under the guidance of the physician for examination and treatment.