Felodipine extended-release tablets and Irbesartan hydrochlorothiazide can be used in combination, can be synergistic lowering blood pressure at the same time offset some of the adverse effects, but the need for joint use should be based on the physician’s diagnosis and treatment advice. Felodipine extended-release tablets and Irbesartan hydrochlorothiazide are both commonly used in the clinic to lower blood pressure. From the mechanism of action, Irbesartan can inhibit vascular tension, diastolic arterial and venous blood vessels; Felodipine can diastolic arterial blood vessels, the two drugs from different target effect, with superimposed blood pressure lowering effect, there is no contraindication to joint use. In terms of side effects, Irbesartan has the effect of lowering glomerular filtration rate and elevating blood potassium, while felodipine has the opposite effect on the kidneys, with the effect of reducing the risk of hyperkalemia caused by Irbesartan; Hydrochlorothiazide, while being diuretic and antihypertensive, is effective in reducing ankle edema caused by dilation of capillaries by felodipine. The combination of two drugs, felodipine extended-release tablets and irbesartan hydrochlorothiazide, is a better combination for patients with hypertension combined with chronic kidney disease, patients with hypertension combined with diabetes mellitus and diabetic nephropathy, and patients with hypertension combined with left ventricular hypertrophy. However, whether it is necessary to use the combination of the above drugs for strong antihypertensive, please follow the doctor’s instructions, do not self-medication.