There are many hypoglycemic drugs, and different hypoglycemic drugs have different time of action, for example, Repaglinide has a time of action of about 4-6 hours, Metformin has a time of action of about 5-6 hours, Metformin extended-release tablets have a time of action of about 8 hours, Glargine has a time of action of about 8 hours, and Glibenclamide has a time of action of about 16-24 hours. The duration of action of hypoglycemic drugs is related to the type and dosage form of hypoglycemic drugs and so on. Diabetic patients must consult a professional doctor before using medication, to combine the actual situation of individual blood sugar to choose drugs, must follow the doctor’s instructions to use medication, avoid unauthorized use of medication, in order to avoid adverse consequences. Regular monitoring of blood glucose is required while taking hypoglycemic drugs.