The patient’s inability to sleep and desire to vomit in the middle of the night may be a sign of sleep disorder and neurological weakness. In this case, the patient can be given symptomatic oral sleeping medication to promote sleep. For example, diazepam, eszopiclone, alprazolam, dexrazopiclone, clonazepam, lorazepam, zolpidem tartrate, etc. can be given orally to improve the patient’s sleep, and the patient’s symptoms of difficulty sleeping and vomiting will then be relieved. The patient’s inability to sleep and desire to vomit in the middle of the night may also be caused by gastrointestinal disorders, where the patient has difficulty sleeping because of physical difficulties. In this case, it may be caused by gastritis or enteritis, etc. Symptomatic treatment is needed to address the symptoms. If the patient has symptoms of nausea and acid reflux, he can take oral pantoprazole. If enteritis is considered, the patient can be given symptomatic oral montelukast for antidiarrheal treatment.