High total bilirubin and direct bilirubin may be caused by obstructive jaundice, malignant tumors of the digestive system and other reasons. 1. Obstructive jaundice: common diseases include common bile duct stone, common hepatic duct stone, biliary roundworm, cholecystitis, etc., which will cause high total bilirubin and direct bilirubin, and is usually accompanied by pain in the right upper abdominal region, fever, nausea, vomiting and other symptoms. 2. Tumors in digestive system: the more common ones are pancreatic head cancer, duodenal papilloma, occupational lesion in duodenal jugular abdomen and other diseases affecting the emptying of bile, resulting in high total and direct bilirubin, which may be accompanied by right upper abdominal cramps, fever, chills and other symptoms. Total bilirubin and direct bilirubin may also be high for physiological reasons, it is recommended to observe dynamically, if it continues to rise or the patient himself has liver and gallbladder diseases, it is recommended to consult a doctor to find out the cause of the disease, and comply with the doctor’s instructions for drug treatment, surgical treatment, so as to avoid delaying the condition.