Sepsis has a high cure rate, but it is still an aggressive disease that can lead to death in the elderly and frail, and in people with underlying diseases such as heart failure and chronic obstructive pulmonary disease (COPD). Sepsis is an acute systemic infection caused by the persistence of pathogenic microorganisms and their toxic products in the bloodstream. The disease can lead to systemic multi-organ dysfunction, and the condition is very dangerous, but nowadays it is possible to control the infection by selecting antibiotics sensitive to the causative organisms through drug sensitivity tests, so the cure rate is high. However, the mortality rate of sepsis is still high for patients who are old and frail, have poor nutritional status, and suffer from underlying diseases such as heart failure, chronic obstructive pulmonary disease, hepatic insufficiency, and diabetes mellitus. If sepsis is diagnosed, please follow the doctor’s instructions for targeted treatment.