If the patient wakes up in the middle of the night with irritability, and the patient is between 45-55 years old, it may be caused by menopause, which is caused by endocrine dysfunction. Patients mainly manifest palpitations, sweating, may also have sleep disorders. It can be manifested as difficulty in falling asleep, easy to wake up during sleep, and more dreams during sleep. You can take oral glutamine and tranquilizing brain tonic to regulate, and if necessary, exercise to regulate. For example, appropriate participation in physical exercise, appropriate outdoor exercise, aerobic exercise before bedtime may improve the symptoms. If necessary, you can also use sedative drugs, such as eszopiclone and diazepam. It may also be caused by neurasthenia, which can occur at any age in this patient. Patients mainly manifest sleep disorders, most patients are caused by prolonged mental tension, stress or overwork. Mainly oral glutamine to regulate, at the same time to instruct the patient to relax, reduce stress, develop a good routine, sleep, get up on time, do not stay up late.