Weakness, drowsiness and swelling may be due to heart disease, kidney disease or endocrine system disease, which need to be analyzed specifically. 1. Heart disease: If cardiac insufficiency occurs, there will be insufficient perfusion of tissues and organs as well as stagnant blood in the circulation, which will lead to weakness, drowsiness and swelling, accompanied by symptoms such as oliguria, dyspnea, coughing and coughing up sputum, etc. Cardiac ultrasound, B-type natriuretic peptide and other tests can assist in making a clear diagnosis. 2. Kidney disease: renal insufficiency, nephritis, nephrotic syndrome and other diseases, due to reduced renal excretory function, hypoproteinemia and other factors, leading to the accumulation of toxins in the body, water and sodium retention, and tissue edema, etc., appearing tired and sleepy and swollen, accompanied by oliguria, hematuria, proteinuria, etc., renal function, urinary ultrasonography, etc., can be used to assist in the definitive diagnosis. 3. Endocrine system diseases: such as hypothyroidism, due to the body’s thyroid hormone level of sugar or thyroid hormone resistance, which led to a generalized low metabolism syndrome, resulting in fatigue, drowsiness and swelling, but also can be accompanied by menstrual disorders, weight gain and other symptoms, thyroid function / ultrasound and other tests can assist in the definitive diagnosis. Thyroid function/ultrasound tests can help to clarify the diagnosis. If there are other reasons for the weakness, drowsiness, and swelling, it is recommended to consult a doctor immediately to avoid delaying the condition.