There are many causes of abdominal leiomyosarcoma, such as genetic factors, muscle fibrous tissue proliferation, drug factors and so on. 1. Genetic factors: abdominal leiomyosarcoma may have some relationship with genetic factors, if the immediate family members suffer from abdominal leiomyosarcoma, then the chances of the patients themselves suffering from abdominal leiomyosarcoma will also be increased. 2. Muscle fiber tissue hyperplasia: trauma to the abdominal muscles may cause muscle fiber tissue hyperplasia, which may lead to abdominal leiomyosarcoma. 3. Drug factors: some patients who take hormonal drugs for a long time, such as estrogen and progesterone, may lead to changes in hormone levels in the body, thus leading to abdominal leiomyosarcoma. The causes of abdominal leiomyosarcoma are many, after diagnosis of the disease, it is recommended that patients go to the hospital in time to improve the examination, take standardized treatment according to the doctor’s instructions, and do not ignore the symptoms, take it lightly, so as not to delay the treatment of the disease.