High levels of both ALT and AST suggest damage to liver cells, which may be caused by viral hepatitis, alcoholic liver disease, drug-induced hepatitis, fatty liver, cirrhosis, and so on. Both ALT and AST are mainly found in liver cells, and when liver cells are damaged for various reasons, they can be released into the blood and increase the blood levels of transaminases. Hepatocytes can be damaged for many reasons, such as acute viral hepatitis, chronic viral hepatitis, alcoholic liver disease, drug-induced hepatitis, fatty liver, cirrhosis, hepatocellular carcinoma, etc., as well as intra-hepatic and extra-hepatic cholestasis due to various reasons, which leads to abnormal liver function. There are many reasons that can cause simultaneous elevation of alanine aminotransferase and glutamine aminotransferase, it is recommended to actively seek medical attention, identify the causes and then actively treat them, avoid unauthorized treatment to delay the condition.