When the submandibular lymph node is enlarged with pus flowing from the mouth, it is recommended to use antibiotics to control the infection while draining the pus through surgery. 1. Antibiotics: swollen lymph nodes with pus suggesting infectious diseases, it is recommended to take antibiotics such as doxycycline, penicillin, azithromycin and other drugs to control inflammation. Drugs need to be used in strict accordance with the doctor’s instructions, the emergence of adverse reactions to timely medical treatment, drug allergy is prohibited. 2. Surgery: The enlarged lymph nodes are recommended to be incised and drained as soon as possible to promote the recovery of the disease, and attention should be paid to keep the drainage smooth, and strict implementation of aseptic operation. Therefore, when the submandibular lymph nodes are enlarged and pus flows from the mouth, it is recommended to go to the hospital as soon as possible to receive treatment, improve the prognosis of the disease and promote the recovery of the disease.