Epididymitis can be treated with either Cephalosporin or Levofloxacin, there is no simple way to determine which drug is better, bacterial cultures and drug sensitivity tests are needed to determine this. Cephalosporin refers to cephalosporin antibiotics, which can have a bactericidal effect and help improve the irritation of the epididymis area from inflammation. Levofloxacin is also used to treat urinary tract infections and epididymitis. Bacterial culture and drug sensitivity test are usually required before using the drug, and patients should choose the appropriate drug treatment under the guidance of the doctor. Allergic people are not allowed to take cephalosporin or levofloxacin, which may cause abdominal discomfort, dizziness and drowsiness and other adverse reactions. Patients with epididymitis should go to the hospital in time and choose the appropriate treatment according to the results of drug sensitivity and bacterial culture under the guidance of the doctor.