Whether creatinine 440umol/L has an effect on life expectancy needs to be judged comprehensively, if the cause of elevated creatinine is acute kidney injury after active treatment, it usually does not affect life expectancy, if it is chronic kidney disease, it may affect life expectancy. If the cause of elevated creatinine is acute, it is necessary to identify and correct reversible factors as soon as possible to avoid further damage to the kidneys, and hemodialysis if necessary, after treatment, part of the patients’ renal function can be restored to normal, and life expectancy is usually not affected. On the other hand, chronic kidney disease has a longer course, when creatinine is 440umol/L, it is equivalent to the stage of renal failure, if the condition is properly controlled, it may not affect the life expectancy; if the condition is progressed to the stage of renal failure, or even the stage of uremia, it will affect the life expectancy. It is suggested that patients with abnormal renal function need to seek medical treatment in time, and the professional nephrologist will make the treatment plan after evaluation, so as to avoid delaying the condition.