Hepatoportal cholangiocarcinoma is a kind of malignant tumor, and the treatment methods include surgery, medication, photodynamic therapy and radiotherapy, etc. Among them, surgery is the most effective means to treat hepatoportal cholangiocarcinoma. 1. Surgical treatment: Surgical treatment is the most important and effective option for this disease. According to the patient’s condition, suitable surgical methods shall be chosen, including radical resection of hepatoportal cholangiocarcinoma, hepatic hilar lymph node dissection, bile duct puncture and drainage, biliary stent implantation, liver transplantation and so on. 2. Drug therapy: such as gemcitabine, cisplatin, methotrexate, which are used to kill cancer cells and improve therapeutic effect. 3. Photodynamic therapy: commonly used in inoperable patients with progressive stage to improve patients’ quality of life. 4. Radiotherapy: radiotherapy is often adopted before and after surgery as a means of auxiliary treatment. 5. Targeted therapy: currently, Lenvatinib can be used for the targeted therapy of hepatoportal cholangiocarcinoma. If cholangiocarcinoma in hilar region is diagnosed, it is recommended to carry out standardized treatment as early as possible in order to reduce the adverse effects of the disease. The above drugs belong to prescription drugs, and must be purchased and used with a doctor’s prescription.