Glioma of corpus callosum is mainly feasible to be treated by surgery and chemotherapy, and can also be combined with the comprehensive treatment methods of radiotherapy, targeted therapy and Chinese medicine. Surgical treatment can remove the diseased tissue and quickly resolve the tumor occupancy in order to reduce the compression of the surrounding nerves and tissues, thus relieving the clinical symptoms, which is of great significance for glioma patients. Studies have shown that the PCV regimen of chemotherapy (procarbazine + lomustine + vincristine) and temozolomide are more effective for gliomas, and can be combined with the integrated treatment methods of radiotherapy, electric field therapy, and traditional Chinese medicine under the guidance of doctors, in order to improve the therapeutic efficacy, the patient’s immunity, as well as the quality of the patient’s survival. It is recommended that patients with glioma of corpus callosum should follow the doctor’s advice and actively treat it.